Kun Qian Lab

Publications (Click to download .pdf)

[80] Su, H.; Li, X.; Huang, L.; Cao, J.; Zhang, M.; Vedarethinam, V.; Di, W.; Hu, Z.; Qian, K. Plasmonic alloys reveal distinct metabolic phenotype of early gastric cancer. Advanced Materials 2021, 33, 2007978.

[79] Deng, J.; Chen, Q.; Chen, Z.; Liang, K.; Gao, X.; Wang, X.; Makota, F.; Sheng, H.; Wan, Y.; Luo, K.; Gong, D.; Yu, X.; Camuglia, S.; Zeng, Q.; Zhou, T.; Xue,F.; He, J.; Wei, Y.; Xiao, F.; Ma, J.; Hill, D.; Pierson, W.; Nguyen, T.; Zhou, H.; Wang, Y.; Shen, W.; Sun, L.; Li, Z.; Xia, Q.; Qian, K.; Ye, L.; Rockman, S.; Linterman, M.; Kedzierska, K.; Shen, N.; Lu, L.; Yu, D. The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses. Nature Communications 2021, 12, 3073.

[78] Zhang, M.; Huang, L.; Yang, J.; Xu, W.; Su, H.; Cao, J.; Wang, Q.; Pu, J.; Qian, K. Ultra-fast label-free serum metabolic diagnosis of coronary heart disease via a deep stabilizer. Advanced Science 2021, 8, 2101333.

‍‍‍[77] Sun, S.; Liu, W.; Yang, J.; Wang, H.; Qian, K. Nanoparticle assisted cation adduction and fragmentation of small metabolites. Angewandte Chemie 2021, 60, ‍11310-11317.1310–11317

[76] Li, X.; Kulkarni, A.; Liu, X.; Gao, W.; Huang, L.; Hu, Z.; Qian, K. Metal-organic framework hybrids aid metabolic profiling for colorectal cancer. Small Methods 2021, 5, 2001001.

[75] Kulkarni, A.; Huang, L.; Qian, K. Material-assisted mass spectrometric analysis of low molecular weight compounds for biomedical applications. Journal of Materials Chemistry B 2021, 9, 3622-3639.

[74] Li, X.; Huang, L.; Qian, K. Nanomaterial-based electrochemical sensors: mechanism, preparation, and application in biomedicine. Advanced NanoBiomed Research 2021, 1, 2000104.

[73] Zhang, C.; Chen, S.; Li, Q.; Wu, J.; Qiu, F.; Chen, Z.; Sun, Y.; Luo, J.; Bastarrachea, R. A.; Grayburn, P. A.; DeFronzo, R. A.; Liu, Y.; Qian, K.; Huang, P. Ultrasound-targeted microbubble destruction mediates gene transfection for beta-cell regeneration and glucose regulation. Small 2021, 17, 2008177.

[72] Han, H.; Yen, H.; Wu, H.; Tan, H.; Xu, W.; Jiang, H.; Tsai, P.; Qian, K.; Wu, Y.; Chen, C. Ultrasensitive detection of Alzheimer’s amyloids on a plasmonic-gold platform. ACS Applied Materials & Interfaces 2021, 13, 57036-57042.

[71] Lan, G.; Yang, J.; Ye, R.; Boyjoo, Y.; Liang, J.; Liu, X.; Li, Y.; Liu, J.; Qian, K. Sustainable carbon materials towards emerging applications. Small Methods 2021, 5, 2001250.

[70] Cao, J.; Shi, X.; Gurav, D.; Huang, L.; Su, H.; Li, K.; Niu, J.; Zhang, M.; Wang, Q.; Jiang, M.; Qian, K. Metabolic fingerprinting on synthetic alloys for medulloblastoma diagnosis and radio therapy evaluation. Advanced Materials 2020, 32, 2000906.

[69] Huang, L.; Wang, L.; Hu, X.; Chen, S.; Tao, Y.; Su, H.; Yang, J.; Xu, W.; Vedarethinam, V.; Wu, S.; Liu, B.; Wan, X.; Lou, J.; Wang, Q.; Qian, K. Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma. Nature Communications 2020, 11, 3556.

[68] Rana, M.; Xu, L.; Cai, J.; Vedarethinam, V.; Tang, Y.; Guo, Q.; Huang, H.; Shen, N.; Di, W.; Ding, H.; Huang, L.; Qian, K. Zirconia hybrid nanoshells for nutrient and toxin detection. Small 2020, 16, 2003902.

[67] Xu, W.; Lin, J.; Gao, M.; Chen, Y.; Cao, J.; Pu, J.; Huang, L.; Zhao, Jing.; Qian, K. Rapid computer-aided diagnosis of stroke by serum metabolic fingerprint based multi-modal recognition. Advanced Science 2020, 7, 2002021.

[66] Vedarethinam, V.; Huang, L.; Zhang, M.; Su, H.; Hu, H.; Xia, H.; Liu, Y.; Wu, B.; Wan, X.; Shen, J.; Xu, L.; Liu, W.; Ma, J.; Qian, K. Vanadium core–shell nanorods inspect metabolic changes of diabetic retinopathy. Advanced Functional Materials 2020, 30, 2002791.

[65] Tan, H.; Hu, H.; Huang, L.; Qian, K. Plasmonic tweezers for optical manipulation and biomedical applications. Analyst 2020, 145, 5699.

[64] Xu, W.; Wang, L.; Zhang, R.; Sun, X.; Huang, L.; Su, H.; Wei, X.; Chen, C.; Lou, J.; Dai, H.; Qian, K. Diagnosis and prognosis of myocardial infarction on a plasmonic chip. Nature Communications 2020, 11, 1654.

[63] Yang, J.; Wang, R.; Huang, L.; Zhang, M.; Niu, J.; Bao, C.; Shen, N.; Dai, M.; Guo, Q.; Wang, Q.; Fu, Q.; Qian, K. Urine metabolic fingerprints encode subtypes of kidney diseases. Angewandte Chemie 2020, 59, 1703-1710.

[62] Huang, L.; Qian, K. Precision diagnosis for the era of personalized medicine. Small Methods 2020, 4, 1900717.

[61] Chen, W.; Li, S.; Kulkarni, A.; Huang, L.; Jing, C.; Qian, K.; Wan, J. Single cell omics: From assay design to biomedical application. Biotechnology Journal 2020, 15, 1900262.

[60] Liu, J.; Cai, C.; Wang, Y.; Liu, Y.; Huang, L.; Tian, T.; Yao, Y.; Wei, J.; Chen, R.; Zhang, K.; Liu, B.; Qian, K. A biomimetic plasmonic nanoreactor for reliable metabolite detection. Advanced Science 2020, 7, 1903730.

[59] Su, H.; Tian, Q.; Hurd Price, C.; Xu, L.; Qian, K.; Liu, J. Nanoporous core@shell particles: Design, preparation, applications in bioadsorption and biocatalysis. Nano Today 2020, 31, 100834.

[58] Liu, W.; Sun, S.; Huang, Y.; Wang, R.; Xu, J.; Liu, X.; Qian, K. Label‐free detection of transferrin receptor by a designed ligand‐protein sensor. Chemistry-An Asian Journal 2020, 15, 56-60.

[57] Wang, L.; Hu, X.; Guo, Q.; Huang, X.; Lin, C.; Chen, X.; Li, M.; Yao, Q.; Zhou, Q.; Wang, J.; Lin, S.; Zhao, G.; Weng, L.; Qian, K.; Lou, J. Clamp‐seq: A novel amplicon‐based NGS assay with concatemer error correction for improved detection of actionable mutations in plasma cfDNA from patients with NSCLC. Small Methods 2020, 4, 1900357.

[56] Zhu, L.; Yang, B.; Qian, K.; Qiao, L.; Liu, Y.; Liu, B. Sensitive electrochemical aptasensor for detecting EpCAM with silica nanoparticles and quantum dots for signal amplification. Journal of Electroanalytical Chemistry 2020, 856, 113655.

[55] Dai, P.; Wang, X.; Gou, T.; Li, Z.; Wen, Z.; Chen, Z.; Hua, M.; Zhong, A.; Wang, L.; Su, H.; Wan, H.; Qian, K.; Liao, L.; Li, J.; Tian, B.; Li, D.; Fu, X.; Shi, H.; Zhou, Y.; Liu, M. A translation-activating function of MIWI/piRNA during mouse spermiogenesis. Cell 2019, 179, 1566-1581.

[54] Huang, L.; Gurav, D.; Wu, S.; Xu, W.; Vedarethinam, V.; Yang, J.; Su, H.; Wan, X.; Fang, Y.; Shen, B.; Price, C.; Velliou, E.; Liu, J.; Qian, K. A multifunctional platinum nanoreactor for point-of-care metabolic analysis. Matter 2019, 1, 1669-1680.

[53] Su, H.; Price, C.; Jing, L.; Tian, Q.; Liu, J.; Qian, K. Janus particles: Design, preparation, and biomedical applications. Materials Today Bio 2019, 4, 100033.

[52] Sun, S.; Wang, R.; Huang, Y.; Xu, J.; Yao, K.; Liu, W.; Cao, Y.; Qian, K. Design of hierarchical beads for efficient label-free cell capture. Small 2019, 34, 1902441.

[51] Zhang, R.; Rejeeth, C.; Xu, W.; Zhu, C.; Liu, X.; Wan, J.; Jiang, M.; Qian, K. Label-free electrochemical sensor for CD44 by ligand-protein interaction. Analytical Chemistry 2019, 91, 7078-7085.

[50] Zhang, R.; Le, B.; Xu, W.; Guo, K.; Sun, X.; Su, H.; Huang, L.; Huang, J.; Shen, T.; Liao, T.; Liang, Y.; Zhang, X.; Dai, H.; Qian, K. Magnetic “squashing” of circulating tumor cells on plasmonic substrates for ultrasensitive NIR fluorescence detection. Small Methods 2019, 3, 1800474.

[49] Gurav, D.; Jia, Y.; Ye, J.; Qian, K. Design of plasmonic nanomaterials for diagnostic spectrometry. Nanoscale Advances 2019, 1, 459-469.

[48] Vedarethinam, V.; Huang, L.; Xu, W.; Zhang, R.; Gurav, D.; Sun, X.; Yang, J.; Chen, R.; Qian, K. Detection and inhibition of bacteria on a dual-functional silver platform. Small 2019, 15, 1803051.

[47] Sun, X.; Huang, L.; Zhang, R.; Xu, W.; Huang, J.; Gurav, D.;Vedarethinam, V.; Chen, R.; Lou, J.; Wang, Q.; Wan, J.; Qian, K. Metabolic fingerprinting on a plasmonic gold chip for mass spectrometry based in vitro diagnostics. ACS Central Science 2018, 4, 223-229.

[46] Zhang, K.; Liu, Y.; Wang, Y.; Zhang, R.; Liu, J.; Wei, J.; Qian, H.; Qian, K.; Chen, R.; Liu, B. Quantitative SERS detection of dopamine in cerebrospinal fluid by dual-recognition-induced hot spot generation. ACS Applied Materials & Interfaces 2018, 10, 15388-15394.

[45] Wu, S.; Qian, L.; Huang, L.; Sun, X.; Su, H.; Gurav, D.; Jiang, M.; Cai, W.; Qian, K. A plasmonic mass spectrometry approach for detection of small nutrients and toxins. Nano-Micro Letters 2018, 10, 52.

[44] Shen, W.; Song, Y.; Burklund, A.; Le, B.; Zhang, R.; Wang, L.; Xi, Y.; Qian, K.; Shen, T.; Zhang, J. Combined immunomagnetic capture coupled with ultrasensitive plasmonic detection of circulating tumor cells in blood. Biomedical Microdevices 2018, 20, 99.

[43] Su, H.; Liu, T.; Huang, L.; Huang, J.; Cao, J.; Yang, H.; Ye, J.; Liu, J.; Qian, K. Plasmonic janus hybrids for detection of small metabolites. Journal of Materials Chemistry B 2018, 6, 7280-7287.

[42] Rejeeth, C.; Pang, X.; Zhang, R.; Xu, W.; Sun, X.; Liu, B.; Lou, J.; Wan, J.; Gu, H.; Yan, W.; Qian, K. Extraction, detection, and profiling of serum biomarkers using designed Fe3O4@SiO2@HA core-shell particles. Nano Research 2018, 11, 68-79.

[41] Li, R.; Gurav, D.; Wan, J.; Qian, K. A coming era of precision diagnostics based on nano-assisted mass spectrometry. Precision Nanomedicine 2018, 1, 162-172.

[40] Huang, L.; Wan, J.; Wei, X.; Liu, Y.; Huang, J.; Sun, X.; Zhang, R.; Gurav, D.; Vedarethinam, V.; Li, Y.; Chen, R.; Qian, K. Plasmonic silver nanoshells for drug and metabolite detection. Nature Communications 2017, 8, 220.

[39] Yan, L.; Qiao, L.; Ji, J.; Li, Y.; Yin, X.; Lin, L.; Liu, X.; Yao, J.; Wang, Y.; Liu, B.; Qian, K.; Liu, B.; Yang, P. In-tip nanoreactors for cancer cells proteome profiling. Analytica Chimica Acta 2017, 949, 43-52.

[38] Wei, X.; Liu, Z.; Jin, X.; Huang, L.; Gurav, D.; Sun, X.; Liu, B.; Ye, J.; Qian, K. Plasmonic nanoshells enhanced laser desorption/ionization mass spectrometry for detection of serum metabolites. Analytica Chimica Acta 2017, 950, 147-155.

[37] Sun, X.; Wan, J.; Qian, K. Designed microdevices for in vitro diagnostics. Small Methods 2017, 1, 1700196.

[36] Rejeeth, C.; Vivek, R.; NipunBabu, V.; Sharma, A.; Ding, X.; Qian, K. Cancer nanomedicine: From PDGF targeted drug delivery. Medchemcomm 2017, 8, 2055-2059.

[35] Pradeepa, S.; Boobalan, M.; Tamilvendan, D.; Sundaraganesan, N.; Sebastian, S.; Qian, K. Spectra, electronic structure and molecular docking investigation son3-(phenyl(p-tolylamino)methyl) naphthalen-2-ol - an experimental and computational approach. Journal of Molecular Structure 2017, 1135, 53-66.

[34] Li, Y.; Wu, J.; Qian, K.; Wu, J.; Liu, B.; Wang, Y.; Zhang, J. Janus graphene hybrids: Fabrication of janus graphene hybrids with controlled structure and high stability. International Journal of Nanomanufacturing 2017, 13, 2.

[33] Zhang, L.; Qian, K.; Wang, X.; Zhang, F.; Shi, X.; Jiang, Y.; Liu, S.; Jaroniec, M.; Liu, J. Yolk-shell-structured aluminum phenylphosphonate microspheres with anionic core and cationic shell. Advanced Science 2016, 3, 1500363.

[32] Wu, J.; Wei, X.; Gan, J.; Huang, L.; Shen, T.; Lou, J.; Liu, B.; Zhang, J.; Qian, K. Multifunctional magnetic particles for combined circulating tumor cells isolation and cellular metabolism detection. Advanced Functional Materials 2016, 26, 4016-4025.

[31] Liu, T.; Qu, L.; Qian, K.; Liu, J.; Zhang, Q.; Liu, L.; Liu, S. Raspberry-like hollow carbon nanospheres with enhanced matrix-free peptide detection profiles. Chemical Communications 2016, 52, 1709-1712.

[30] Liu, B.; Li, Y.; Wan, H.; Wang, L.; Xu, W.; Zhu, S.; Liang, Y.; Zhang, B.; Lou, J.; Dai, H.; Qian, K. High performance, multiplexed lung cancer biomarker detection on a plasmonic gold chip. Advanced Functional Materials 2016, 26, 7994-8002.

[29] Li, Y.; Yan, L.; Liu, Y.; Qian, K.; Liu, B.; Yang, P.; Liu, B. High-efficiency nano/micro-reactors for protein analysis. RSC Advances 2015, 5, 1331-1342.

[28] Gan, J.; Wei, X.; Li, Y.; Wu, J.; Qian, K.; Liu, B. Designer SiO2@Au nanoshells towards sensitive and selective detection of small molecules in laser desorption ionization mass spectrometry. Nanomedicine: Nanotechnology, Biology, and Medicine 2015, 11, 1715-1723.

[27] Qian, K.; Zhou, L.; Zhang, J.; Lei, C.; Yu, C. A combo-pore approach for the programmable extraction of peptides/proteins. Nanoscale 2014, 6, 5121-5125.

[26] Lei, C.; Noonan, O.; Jambhrunkar, S.; Qian, K.; Xu, C.; Zhang, J.; Nouwens, A.; Yu, C. Sensitive detection of human insulin using a designed combined pore approach. Small 2014, 10, 2413-2418.

[25] Bian, X.; Qian, K.; Liao, L.; Zhou, X.; Guo, K.; Huang, X.; Yu, C.; Ji, C.; Liu, B. Platinum nanoparticles supported on hierarchical carbon foams for electrocatalytic oxidation of methanol. ECS Electrochemistry Letters 2014, 3, F11-F14.

[24] Zhou, L.; Xu, H.; Zhang, H.; Yang, J.; Hartono, S.; Qian, K.; Zou, J.; Yu, C. Cheap and scalable synthesis of alpha-Fe2O3 multi-shelled hollow spheres as high-performance anode materials for lithium ion batteries. Chemical Communications 2013, 49, 8695-8697.

[23] Qian, K.; Zhou, L.; Liu, J.; Yang, J.; Xu, H.; Yu, M.; Nouwens, A.; Zou, J.; Monteiro, M.; Yu, C. Laser engineered graphene paper for mass spectrometry imaging. Scientific Reports 2013, 3, 1415.

[22] Qian, K.; Liu, F.; Yang, J.; Huang, X.; Gu, W.; Jambhrunkar, S.; Yuan, P.; Yu, C. Pore size-optimized periodic mesoporous organosilicas for the enrichment of peptides and polymers. RSC Advances 2013, 3, 14466-14472.

[21] Lei, C.; Qian, K.; Noonan, O.; Nouwensa, A.; Yu, C. Applications of nanomaterials in mass spectrometry analysis. Nanoscale 2013, 5, 12033-12042.

[20] Gan, J.; Qian, K.; Wan, J.; Qiao, L.; Guo, W.; Yang, P.; Girault, H.; Liu, B. Amino-functionalized macroporous silica for efficient tryptic digestion in acidic solutions. Proteomics 2013, 13, 3117-3123.

[19] Qian, K.; Gu, W.; Yuan, P.; Liu, F.; Wang, Y.; Monteiro, M.; Yu, C. Enrichment and detection of peptides from biological systems using designed periodic mesoporous organosilica microspheres. Small 2012, 8, 231-236.

[18] Huang, X.; Zhou, X.; Qian, K.; Zhao, D.; Liu, Z.; Yu, C. A magnetite nanocrystal/graphene composite as high performance anode for lithium-ion batteries. Journal of Alloys and Compounds 2012, 514, 76-80.

[17] Huang, X.; Qian, K.; Yang, J.; Zhang, J.; Li, L.; Yu, C.; Zhao, D. Functional nanoporous graphene foams with controlled pore sizes. Advanced Materials 2012, 24, 4419-4423.

[16] Yang, J.; Zhou, L.; Zhao, L.; Zhang, H.; Yin, J.; Wei, G.; Qian, K.; Wang, Y.; Yu, C. A designed nanoporous material for phosphate removal with high efficiency. Journal of Materials Chemistry 2011, 21, 2489-2494.

[15] Wang, Y.; Qian, K.; Guo, K.; Kong, J.; Marty, J.; Yu, C.; Liu, B. Electrochemistry and biosensing activity of cytochrome c immobilized in macroporous materials. Microchimica Acta 2011, 175, 87-95.

[14] Pan, D.; Zhao, L.; Qian, K.; Tan, L.; Zhou, L.; Zhang, J.; Huang, X.; Fan, Y.; Liu, H.; Yu, C.; Bao, X. A silanol protection mechanism: Understanding the decomposition behavior of surfactants in mesostructured solids. Journal of Materials Research 2011, 26, 804-814.

[13] Liu, F.; Yuan, P.; Wan, J.; Qian, K.; Wei, G.; Yang, J.; Liu, B.; Wang, Y.; Yu, C. Periodic mesoporous organosilicas with controlled pore symmetries for peptides enrichment. Journal of Nanoscience and Nanotechnology 2011, 11, 5215-5222.

[12] Huang, X.; Zhou, X.; Zhou, L.; Qian, K.; Wang, Y.; Liu, Z.; Yu, C. A facile one-step solvothermal synthesis of SnO2/graphene nanocomposite and its application as an anode material for lithium-ion batteries. Chemphyschem 2011, 12, 278-281.

[11] Hu, Y.; Qian, K.; Yuan, P.; Wang, Y.; Yu, C. Synthesis of large-pore periodic mesoporous organosilica. Materials Letters 2011, 65, 21-23.

[10] Guo, W.; Wan, J.; Qian, K.; Yu, C.; Kong, J.; Yang, P.; Liu, B. TiO2-functionalized mesoporous materials for sensitive analysis of multi-phosphopeptides. Science China-Chemistry 2011, 54, 1327-1333.

[9] Guo, W.; Bi, H.; Qiao, L.; Wan, J.; Qian, K.; Girault, H.; Liu, B. Characterization of efficient proteolysis by trypsin loaded macroporous silica. Molecular Biosystems 2011, 7, 2890-2898.

[8] Guo, K.; Qian, K.; Zhang, S.; Kong, J.; Yu, C.; Liu, B. Bio-electrocatalysis of NADH and ethanol based on graphene sheets modified electrodes. Talanta 2011, 85, 1174-1179.

[7] Zhang, J.; Yu, M.; Yuan, P.; Wang, H.; Qian, K.; Tan, L.; Wang, Y.; Yu, C. Tuning cooperative vesicle templating and liquid crystal templating simply by varying silica source. Journal of Materials Research 2010, 25, 648-657.

[6] Wan, J.; Qian, K.; Zhang, J.; Liu, F.; Wang, Y.; Yang, P.; Liu, B.; Yu, C. Functionalized periodic mesoporous organosilicas for enhanced and selective peptide enrichment. Langmuir 2010, 26, 7444-7450.

[5] Qian, K.; Wan, J.; Huang, X.; Yang, P.; Liu, B.; Yu, C. A smart glycol-directed nanodevice from rationally designed macroporous materials. Chemistry-A European Journal 2010, 16, 822-828.

[4] Pan, D.; Tan, L.; Qian, K.; Zhou, L.; Fan, Y.; Yu, C.; Bao, X. Synthesis of highly ordered and hydrothermally stable mesoporous materials using sodium silicate as a precursor. Materials Letters 2010, 64, 1543-1545.

[3] Wan, J.; Qian, K.; Qiao, L.; Wang, Y.; Kong, J.; Yang, P.; Liu, B.; Yu, C. TiO2-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides. Chemistry-A European Journal 2009, 15, 2504-2508.

[2] Qian, K.; Wan, J.; Qiao, L.; Huang, X.; Tang, J.; Wang, Y.; Kong, J.; Yang, P.; Yu, C.; Liu, B. Macroporous materials as novel catalysts for efficient and controllable proteolysis. Analytical Chemistry 2009, 81, 5749-5756.

[1] Qian, K.; Wan, J.; Liu, F.; Girault, H.; Liu, B.; Yu, C. A phospho-directed macroporous alumina-silica nanoreactor with multi-functions. ACS Nano 2009, 3, 3656-3662.